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P. Vinod Kumar*, Prasanna Kumar Desu, K. Nagaraju, T. Maheswari, E. Shasi and P. Venkateswara Rao


The purpose of this study was to design and optimise an oral controlled release Nebivolol mucoadhesive tablet by using HPMC K4M, CArbopol-940 and Hydroxy Methyl Cellulose as mucoadhesive polymers, which significantly influence characteristics like swelling index, exvivo mucoadhesive strength and in-vitro drug release. Tablets were prepared by direct compression and evaluated for mucoadhesive strength and in-vitro dissolution parameters. A total of nine formulations were developed with varying concentration of polymers. Pre-formulation study was carried out for powder blends and it was evaluated to determine the flow characteristics by bulk density, tapped density, Hausner’s ratio, Carr’s index and angle of repose. The results obtained from these studies indicated that the powder blend had good flow properties. The Mucco adhesive buccal tablets were prepared with different ratios of polymers by direct compression method. The formulated tablets were evaluated for physical characterization like thickness, hardness, friability, weight variation and drug content, swelling index, bio –adhesive strength, Ex-vivo retention time, dissolution. All the physical parameters of prepared Mucco adhesive buccal tablets comply with IP specifications. The formulated tablets were evaluated for drug content and it was found to be in the range of 94% w/w. Thus, all formulation of Nebivolol was found to be within the acceptable range. The optimized formulation (F6) had shown the satisfactory release of drug. The drug polymer interaction study was carried out by FTIR study. From the report it was concluded that there was no interaction between drug and polymers used in the formulations.

Keywords: Nebivolol, Carbopol, Hydroxy Propyl Methyl Cellulose and and Hydroxy Ethyl Cellulose.

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