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Abstract

ORIGIN OF RELATED SUBSTANCES DURING THE PREPARATION OF 2’-DEOXY-2’-?- FLUORO-2’-?-C-METHYL-3’,5’-CYCLIC PHOSPHATE NUCLEOTIDE

Sureshbabu Jayachandra, Madhuresh Kumar Sethi*, Vipin Kumar Kaushik, Vijaya
Krishna Ravi, Vikas Chandra Dev, Saiprasad Kottolla, P. V. Srinivasa Rao and Purbita
Chakraborty

ABSTRACT

This manuscript aims to comprehensively illustrate/evaluate the related substances stimulated during preparation of 2’-Deoxy-2’-α-fluoro-2’- β-C-methyl 3’,5’-cyclic phosphate nucleotide, a drug related substance from N-Benzoyl-3',5'-di-O-benzoyl-2'-deoxy-2'-fluoro-2'- methylcytidine (OR) 2'-Deoxy-2'-fluoro-2'-methyl-N- (phenylcarbonyl)-3',5'-bis O-(phenylcarbonyl)cytidine (OR) Cytidine, N-Benzoyl-2’-deoxy-2’-fluoro-2’methyl-,3’,5’-dibenzoate, (2’R)-, an intermediate i.e. Compound 5 and subsequently their synthesis.

Keywords: Benzoyl (Bz), Cinnamoyl (Cin); Hepatitis C virus (HCV); HCV NS5B polymerase; nucleoside Phosphoramidate; 2’-Deoxy-2’-?-fluoro-2’-?-C-methyl-3’,5’- cyclicphosphate nucleotide.


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