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  • WJPPS MARCH ISSUE PUBLISHED
  • MARCH 2019 Issue has been successfully launched on 1 March 2019

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  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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Abstract

FORMULATION AND IN VITRO EVALUATION OF FLOATING TABLETS OF RANITIDINE HCL USING DIFFERENT POLYMERS

Saurabh Mandowara*, Sanjay K. Sharma, Manish Jaimini, Bhupendra Singh Chauhan, Shailender Mohan

ABSTRACT

The present investigation is an attempt made to develop the floating tablets of Ranitidine HCl, which after oral administration, prolongs the gastric residence time and increases the bioavailability of the drug. Preliminary trial batches were prepared and the best combination was selected on the basis of the floating behavior (floating lag time, total floating time). The batches of tablets were fabricated containing drug, and various grades of polymers viz. HPMC K4M, HPMC K15 M, HPMC K100M, guar gum and chitosan along with gas generating agent sodium bicarbonate. The formulations were prepared by using direct compression technique to study the effect of these polymers on floating behaviors as well as release. The physicochemical properties of different formulations, their buoyancy lag time, total floatation time and swelling index were evaluated. The in vitro release studies indicated that the formulation F6 containing chitosan with sodium bicarbonate (effervescing compound) showed good drug release rate marking up to 10 hrs in comparison to other batches. The results indicate that gas powered hydro-dynamically balanced tablets of Ranitidine HCl containing chitosan provides a better option for controlled release action and improved bioavailability.

Keywords: Floating drug delivery system, Ranitidine HCl, Hydro-dynamically Balanced System, Bioavailability, Chitosan.


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