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Abstract

FORMULATION AND EVALUATION OF NOVEL LIPID BASED SOLID-SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM OF AGOMELATINE

Rajat J. Gadhave* and K. N. Tarkase

ABSTRACT

The present studies are based on formulation and evaluation of Solid–Self Nanoemulsifying Drug Delivery System (S- SNEDDS) of agomelatine as antidepressant. The main aim of the studies was to increase the solubility of the pure drug sample of Poorly water soluble drug agomelatine. In this studies novel liquid formulation of S- SNEDDS containing Agomelatine was furthers converted into solid by using Solid adsorption carrier techniques. Solubility of Agomelatine was checked in various oil, surfactant and co-surfactant. Pseudo ternary phase diagrams was constructed using oil (Isopropyl myristes), Surfactant (Labrasol) Co-Surfactant (PEG-400). The prepared Agomelatine loaded. SNEDDS formulation were evaluated for viscosity, Refractive Index, globule size, Zeta potential and SEM. The optimized Liquid- SNEDDS formulation was converted into solid SNEDDS by Solid adsorption carrier techniques using Talc as adsorbent. The prepared S- SNEDDS were evaluated for rheological properties and characterization of S- SNEDDS. FT-IR, DSC and Powder XRD studies were carried. Dissolution Studies Showed that S-SNEDDS enhanced the solubility of Agomelatine as Compared to the pure drug sample.

Keywords: Agomelatine, Solid self-Nanoemulsifying drug delivery system, Adsorption, Ternary Phase Diagram, solubility.


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