FORMULATION AND IN-VITRO EVALUATION OF MUCOADHESIVE BUCCAL TABLETS OF FUROSEMIDE
*Bhaskar Umarji, Rudragouda Patil, Ravindra Birajdar, Swati Mysore, Siddramesh Bilagi, Dhananjay Audurti.
Dept. of Pharmaceutics, B.L.D.E.A’s College of Pharmacy, BLDE University Campus, Bijapur- 586 103, Karnataka, India.
ABSTRACT
The objective of the study was to develop mucoadhesive buccal tablet
of furosemide. Tablets of Furosemide were prepared by wet
granulation method using mucoadhesive polymers like Carbopol
934P, Guar Gum, Chitosan, Hydroxy Ethyl Cellulose, in different
ratios. Buccal tablets were evaluated by different methods for
parameters such as thickness, hardness, weight uniformity, drug
content uniformity, swelling index, surface pH, ex vivo mucoadhesive
strength, ex vivo residence time, in vitro drug release, ex vivo drug
permeation, stability studies. The tablets were evaluated for in vitro
release in pH 6.8 phosphate buffer for 12 hr in standard dissolution
apparatus. Mucoadhesion strength was increased with increase in the
concentration of carbopol. In order to determine the mode of release,
the data was subjected to Zero order, first order, Higuchi and Peppas
diffusion model.
Short-term stability studies on the promising formulations indicated that there were no
significant changes in drug content, ex-vivo mucoadhesive strength and in vitro dissolution
characteristics. IR spectroscopic studies indicated that there were no drug-excipient
interactions. The prepared buccal tablets of furosemide could stay in the buccal for a longer
period of time, which indicate a potential use of mucoadhesive tablets of furosemide for
treating Hypertensive patients.
Keywords: Mucoadhesive buccal tablet; Furosemide; Swelling index; Mucoadhesive strength; Carbopol 934P.
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