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Priyadarshini Chirag Patel*, Sapna Dhruv Desai, Ankita Anish Desai


The objective of the present research work was to develop and optimize a sublingual tablet of Esomeprazole sodium which is indicated for the treatment of gastro oesophageal reflux disease, by direct compression method. The tablets were prepared using four different superdisintegrants such as sodium starch glycolate, cross carmellose sodium, crosspovidone and Indion 414. The prepared tablets were evaluated for their physical characteristics and in vitro drug release properties. In vitro release study was carried out using USP dissolution apparatus 2. The results revealed that the batch of tablets (F-13) formulated containing Indion 414 provides short wetting time of 8.2 seconds and in vitro disintegration time of 18.7 seconds, which facilitates its faster disintegration and drug content of 99.54%, and in-vitro drug release was found to be in formulation F-13 i.e. 99.86% within 120 seconds. From the above results, it indicate that Formulation F-13 emerged as the overall best formulation based on drug release characteristics with pH 6.8 phosphate buffer as dissolution medium. Stability studies were carried out which indicated that the selected formulation F-13 was found to be stable.

Keywords: Sublingual tablet, Esomeprazole sodium, Gastro oesophageal reflux disease, Superdisintegrant, Indion 414.

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