Photo Gallery

Login

Search

News & Updation

  • WJPPS OCTOBER ISSUE PUBLISHED
  • OCTOBER 2018 Issue has been successfully launched on 1 October 2018

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  

Abstract

FORMULATION AND EVALUATION OF TOPICAL GEL DELIVERY OF LORNOXICAM

Dharmendra Singh*, Anupam Kr. Sachan and Sunil Kumar

ABSTRACT

The aim of the present research work is to prepare and evaluate topical hydrogel of lornoxicam using different gelling agent for the treatment of inflammation. Lornoxicam is a highly selective cyclooxigenase-1 & cyclooxigenase-2 inhibitor used in the treatment of inflammation, pain and edema, rheumatoid arthritis and so on. Topical gel of Lornoxicam was formulated using triethanolamine (5%) as solvent, carbopol 934p as gelling polymer and various penetration enhancers. Formulated gel was evaluated with respect to different physiochemical parameters such as pH, viscosity, spreadability, gel strength. The in-vitro drug release rate of gel was evaluated using Franz diffusion cell with phosphate buffer 7.4 as the receptor medium. Stability studies carried out at different temperatures and humidity did not show any significant change in drug content, % CDR, viscosities and other parameters at the end of 12 weeks indicating that all the formulations were stable. It was concluded that Physiochemiclly stable and non-irritant Lornoxicam gel was formulated and the drug release increased with increase in concentration of penetration enhancer which is suitable for topical application.

Keywords: Lornoxicam, hydrogel, Penetration enhancers, in-vitro, penetration enhancer, inflammation.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More