Abstract

HAEMATOLOGICAL EFFECTS OF OCIMUM SANCTUM (INFLORESCENCE OF TULSI) ON MICE

Komal Sawariya, Virendra Kumar Vishwakarma and Yatindra Kumar*

ABSTRACT

Ocimum sanctum commonly called as „holy basil‟ in English and „Tulsi‟ in Hindi is a many branched, erect, stout and aromatic herb about 70 cm high, small sweet scented herb found throughout India and cultivated at a large scale. Ocimum sanctum has been used for a wide range of ailments in traditional medicine. The research study was undertaken to investigate the effect of different dose schedules by orally administration 70% ethanolic inflorescence extract of Tulsi (Ocimum sanctum) on haematological changes of chronic poisoning in adult albino mice (85-90 gm) and 10 weeks of age male sex. The experimental mice were divided into three groups the first group C1 received without the inclusion of the inflorescence of Ocimum sanctum (control group), whereas the second group C2 received a dose containing 150 mg/kg/day and third group C3 received a dose of 600 mg/kg/week. Doses of Ocimum sanctum extract were administered daily by oral gavage in the volume of 10 ml/kg body weight, once daily for 21 consecutive days. There were no statistically significant differences in the studied parameters between two groups. The mean Hb, RBC and Platelet value were reduced significantly (P<0.05) in ethanolic extract treated mice, MCV and MCH values were initially increased in group C2 than after decreased in group C3 and noticed a significant improvement in both of treated groups C2 & C3 (P<0.05) PCV and WBC values were found as dose dependent manner.

Keywords: Ocimum Sanctum (Inflorescence), Haematological Alterations, Mice.