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  • WJPPS JUNE ISSUE PUBLISHED
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Abstract

EXTRACTION SPECTROPHOTOMETRIC DETERMINATION OF ESCITALOPRAM DRUG BY ION PAIR COMPLEX METHOD WITH BROM CRESOL GREEN DYE IN TABLET DOSAGE FORM AND PHARMACEUTICAL FORMULATION

Nuzhath Fathima*, P. Raveendra Reddy and G. Abdul Huq

ABSTRACT

A simple Extraction Spectrophotometric method has been developed for the determination of Escitalopram in pharmaceutical formulations and in the tablet dosage form using Bromo Cresol Green (BCG). The interaction of the drug with BCG in the presence of Sodium Acetate-HCl buffer solution of pH 3.5 results in the formation of an ion- pair complex which is extracted into Chloroform and the composition of which is established as 1:1 (Drug: BCG) by Job’s continuous variation method. The wavelength of maximum absorbance of the extracted Ion-pair complex is found to be 400 nm. The absorbance values of the extracted Ion-pair complex are found to increase linearly with the increase in the amount of the drug Escitalopram in the range 5 μg/mL to 35 μg/mL. This suggests the suitability of the proposed method for the determination of Escitalopram in the range 5 μg/mL to 35 μg/mL. Further it also confirms the obedience of Beer-Lambert’s law in this range. The method is successfully employed to evaluate the assay of commercial tablets in pharmaceutical formulations for Escitalopram and the results agreed very well. The molar absorptivity and Sandell Sensitivity of the method are 8.887x103 lit.mol-1.cm-1 and 0.0365 μg.cm-2 respectively.

Keywords: Extraction Spectrophotometry, Escitalopram, Ion-pair complex, Bromo Cresol Green, Pharmaceutical formulations.


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