Photo Gallery

Login

Search

News & Updation

  • WJPPS AUGUST ISSUE PUBLISHED
  • AUGUST 2018 Issue has been successfully launched on 1 August 2018

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  

Abstract

UV- SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION OF BENFOTIAMINE IN BULK AND PHARMACEUTICAL DOSAGE FORMS

*Swaroopa H. M., Sagar G., Prajwal H. K., Sanjana S. and Jithin Jose A.

ABSTRACT

A simple, sensitive, accurate and precise Area under curve spectroscopy method was developed for the estimation of Benfotiamine in bulk and tablet dosage form. This method, involves the measurement of absorbances of Benfotiamine at the wavelength of 239-249 nm. 0.1 M HCl was used as solvent. Linearity was observed in the concentration range of 3-18 μg/ml with correlation coefficient 0.999. The method was validated for linearity, precision, accuracy, limit of detection, limit of quantitation and ruggedness. The accuracy of the method was confirmed by recovery studies of tablet dosage forms and was found to be 99.30%-100.51% for Benfotiamine. The method showed good reproducibility and recovery with % RSD less than 2.0. The limit of detection and limit of quantitation for estimation of Benfotiamine was found to be 0.122 μg/ml and 0.372 μg/ml. Thus the developed method was successfully applied for the estimation of Benfotiamine in pure and pharmaceutical dosage form.

Keywords: Benfotiamine, Area under curve Spectroscopy, 0.1MHCl, accuracy.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More