Abstract

CHICORIC ACID AND ITS ANALOGUES AS AN ANTI-HIV INTEGRASE AGENTS

*Nadim M. R. Chhipa, Krupa M. Patel, Sachin P. Ganchi and Prof. Dr. Dhrubo Jyoti Sen

ABSTRACT

Human immunodeficiency virus (HIV) integrase (IN) catalyzes the integration of HIV DNA copy into the host cell DNA. It is an essential enzyme required for replication and further development of the AIDS virus. HIV-1 Integrase becomes a potential target for anti-HIV therapy. L-Chicoric acid has been found to be one of the most potent HIV-1 integrase inhibitor. Chicoric acid and its analogues act against HIV integrase and thus have the potential to become a part of anti-HIV drug regime. Chicoric acid analogues have all the structural features required for it to act as good anti–HIV agent like poly aromatic rings and a central linker.

Keywords: Integrase, Chicoric acid, HIV, Strand Transfer.