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  • WJPPS AUGUST ISSUE PUBLISHED
  • AUGUST 2018 Issue has been successfully launched on 1 August 2018

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Abstract

SPECTROPHOTOMETRIC OXIDATION METHOD FOR THE DETERMINATION OF TAMSULOSIN IN THE PRESENCE OF DUTASTERIDE BY USING BROMATE – BROMIDE MIXTURE

I. Lakshmi Prasanna*, G.T. Naidu, Nuzhath Fathima, I.E.Chakravarthy and G. Abdul Huq

ABSTRACT

sensitive, precise, accurate, simple and rapid spectrophotometric method has been developed for the estimation of Tamsulosin in the presence of Dutasteride in pharmaceutical formulations and in the drug dosage form. During the course of study, it is observed that acidic solution of the drug formed the oxidation product with Bromate – Bromide mixture. This property of the drug is exploited for the development of spectrophotometric method for the determination and analysis of the drug. The oxidation product showed λmax at 320 nm. The linearity range for Tamsulosin in the presence of Dutasteride is found to be 20 μg/ml to 300 μg/ml. Recovery studies gave satisfactory results indicating that none of common additives and excipients interfere the assay method. The molar absorptivity and the sandell sensitivity of the method are evaluated and the values are found to be to be 2.0691 ×104 lit/mole/cm and 0.0215μg/ml/cm2 respectively.

Keywords: Spectrophotometry, Tamsulosin, Dutasteride, Bromate-Bromide oxidant, Pharmaceutical formulations.


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