WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

SOLID STATE CHARACTERIZATION AND IN VITRO DISSOLUTION ENHANCEMENT OF IRBESARTAN BY SOLID DISPERSION ADSORBATE TECHNIQUE

Dipak R. Yadav* and Dr. S. K. Shah

ABSTRACT

Various processes were used for the solubility enhancement of Irbesartan, solid dispersion adsorbate technique is one of them. The improvement in solubility and in-vitro drug release were observed. The in-vitro drug release of solid dispersion adsorbate of PEG 4000 and Poloxamer 188 prepared by fusion method was significantly improved the dissolution compared to solid dispersion of PVP K-30 and pure drug. The in-vitro release studies showed 90% of drug release in 30 minutes. Solid-state characterization based on FT-IR spectroscopy, DSC and in vitro dissolution study was carried out to investigate the mechanisms of carrier dissolution enhancement. Enhanced Solubility and dissolution rate of Irbesartan show dissolution rate limited absorption and the onset of action is beneficial to treat hypertensive patients. Overall, the formulations FENPEG (1:3) and FENPOL (1:3) which showed better in-vitro dissolution profile, lower MDT and f2 values. Tablets of FENPEG (1:3) prepared and compared with pure drug tablets and marketed formulation. Tablets of FENPEG (1:3) gives highest drug release 99% in 60 min. additionally the prepared tablets checked for stability study and found stable after 1 month. Hence, based on above results it concluded that the FENPEG (1:3) was optimized formulation.

Keywords: Solid Dispersion, Adsorbate, Irbesartan.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More