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Abstract

FORMULATION AND EVALUATION OF FLOATING BI-LAYER TABLETS OF BERBERINE HYDROCHLORIDE AND ALOE VERA GEL POWDER

Yatin K. Prajapati* and Dr. S. K. Shah

ABSTRACT

In present investigation, an attempt was made to deliver Berberine HCl and Aloe Vera gel via floating drug delivery system to the vicinity of absorption site by prolonging the gastric residence time of the dosage form. Bilayer Tablets were subjected to various evaluation parameters such as hardness, friability, thickness, density, weight variation, drug content, floating property study, swelling study, In vitro drug release study. It was revealed that tablets of all batches had acceptable physical parameters. The effervescent-based gastro retentive drug delivery is a promising approach to achieve In vitro buoyancy by using gel-forming polymer HPMC K4M, HPMC K100M, Carbopol, guar gum, Polyethylene oxide and gas generating agent as sodium bicarbonate. Fourier transform Infrared spectroscopy confirmed the absence of any drug/polymers/excipients interactions. The drug content of all the formulations was found to be in the range of 96.22% to 99.45%. In vitro floatability studies revealed that most of the tablets still floated for more than 8 hours because of their low densities. In vitro drug release studies were performed for all the prepared formulations. All the prepared floating tablets exhibited good drug release. Amount of polymer in floating tablet plays an important role in drug release. Low amount of polymer in formulation doesn‟t make a tablet to release a drug up to 8 hr. so F21 formulation in combination of HPMC K 100M and HPMC K4 M makes tablet float and release a drug up to 8hr. additionally the F21 formulation found stable during stability study. Hence based on above conclusion, F21 formulation is optimized formulation.

Keywords: Berberine HCl, Aloe Vera, floating, Bilayer tablets.


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