Photo Gallery

Login

Search

News & Updation

  • WJPPS AUGUST ISSUE PUBLISHED
  • AUGUST 2018 Issue has been successfully launched on 1 August 2018

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  

Abstract

DESIGN AND CHARECTARISATION OF FAST DISSOLVING SUBLINGUAL FILM OF PERINDOPRIL ERBUMINE USING VARIOUS POLYMERS

Shabaraya A. R., Vinayak K.* and Harsha

ABSTRACT

Sublingual route is the one among the most significant route of administration of drugs especially for those which need to avoid the first pass metabolism and required in lesser doses. Here the attempt was made to formulate fast dissolving sublingual film of Perindopril erbumine an antihypertensive agent belongs to ACE inhibitors by solvent casting method using different concentration of polymers HPMC E15, Pullulan for increase the convenience and compliance to the elderly and dysphagic patients and evaluated for the drug polymer compatibility by FTIR studies. The prepared films were evaluated for physico-chemical parameters such as weight uniformity, thickness uniformity, folding endurance, In-vitro disintegration time, In-vitro dissolution studies and In-vitro permeation studies. Skin irritation and stability studies were performed. It was found that all characteristic features show significant results. Formulation F1 and F7 showing best release of 95.93% and 92.47% at the end of 180sec respectively. In-vitro permeation studies of F1 formulation showed highest drug permeation of 93.97% at the end of 5min. No significant change was observed in the physical appearance, drug content, and In-vitro dissolution studies during stability studies at 40±20˚C/75±5% RH up to 90 days.

Keywords: Perindopril erbumine, sublingual film, ACE-inhibitor, physicochemical parameters.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More