Photo Gallery

Login

Search

News & Updation

  • WJPPS AUGUST ISSUE PUBLISHED
  • AUGUST 2018 Issue has been successfully launched on 1 August 2018

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  

Abstract

DEVELOPMENT AND VALIDATION OF Q-ABSORBANCE RATIO METHOD FOR THE SIMULTANEOUS ESTIMATION OF SOFOSBUVIR AND DACLATASVIR DIHYDROCHLORIDE IN SOLID DOSAGE FORM

Khushbu S. Bhavsar* and Paresh U. Patel

ABSTRACT

A simple and sensitive Spectrophotometric method based on Q-Absorbance Ratio Method was developed for the simultaneous estimation of Sofosbuvir and Daclatasvir dihydrochloride in solid dosage form. This method was based on the formation of Q- Absorbance equation at two wavelengths, one was Isoabsorptive Point and another one was λmax of one of them. So, λ1 was 273 nm and λ2 was 261 nm. and Daclatasvir dihydrochloride were comply with the Beer’s Lambert’s law over the linearity range 4-32 μg/ml. The method was validated as per International Conference on Harmonization (ICH) guidelines. The parameters of ICH guidelines are Linearity, Precision (Repeatability and Reproducibility), Limit Of Detection (LOD), Limit Of Quantitation (LOQ) and Accuracy. All parameters were found to be within the accepted limits. The method was found to be simple, rapid, sensitive, precise, accurate and cost effective for use in routine analysis of both drugs in pharmaceutical dosage form.

Keywords: Sofosbuvir, Daclatasvir dihydrochloride, Q-Absorbance Ratio method, Methanol: Water (50:50).


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More