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Abstract

DEVELOPMENT AND CHARACTERIZATION OF TELMISARTAN TABLET BY THE USE OF CO-CRYSTALLIZATION TECHNIQUE

Sarang R. Masodkar*, Shrikant D. Pande and Sandeep C. Atram

ABSTRACT

Telmisartan is an angiotensin II receptor antagonist (angiotensin receptor blocker, ARB) used in the management of hypertension. Telmisartan belongs to class II drug in BCS classification i.e. low solubility and high permeability. One of the major problems with this drug is its low solubility in biological fluids, which results into poor bioavailability after oral administration. The purpose of this study was to prepare pharmaceutical co-crystals of Telmisartan to enhance solubility and dissolution rate of Telmisartan. Co-crystallization is an effective crystal engineering approach for modifying the crystal structure and properties of drugs. Pharmaceutical co-crystals are nonionic supramolecular complexes and can be used to altered physical property issues such as solubility, stability and bioavailability in pharmaceutical development without affecting chemical composition of API. Co-crystallization can improve physiochemical properties like solubility, dissolution rate, chemical stability and melting point.

Keywords: Co-crystals, Telmisartan, Co-former, Solubility, Invitro-Dissolution.


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