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  • WJPPS OCTOBER ISSUE PUBLISHED
  • OCTOBER 2018 Issue has been successfully launched on 1 October 2018

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  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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Abstract

SYNTHESIS AND CHARACTERIZATION OF SOME NEW THIAZOLIDINONES CONTAINING COUMARIN MOIETY AND THEIR ANTIMICROBIAL STUDY

S. P. Kushwaha* and Dr. Sokindra Kumar

ABSTRACT

A novel thiazolidinones series have been synthesized by reaction of different Schiff bases of coumarin with iodoacetic acid. The reaction of 4-hydroxy coumarin with phosphorus pentachloride (PCl5) yielded 4-chloro coumarin 2 and 4-chloro-3, 4', 3', 4"-tercoumarin 2a. Compound 2 was reacted with p-toluenediamine sulfate to give 4-[(4-aminophenyl)amino]-2H-chromen-2-one. Various Schiff bases of coumarin were synthesized by condensation of 4-[(4-aminophenyl)amino]-2H- chromen-2-one with different aldehydes. The structures of the newly synthesized compound were confirmed by IR, 1H NMR, 13C NMR and C, H, N analysis. The thiazolidinone derivatives were evaluated for their anti bacterial and antifungal activity by broth dilution method.

Keywords: Coumarin, Schiff bases, thiazolidinone, antibacterial, antifungal.


[Full Text Article]

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