NON-DEGRADABLE POLYMER BASED MICROPARTICLES CONTAINING WATER SOLUBLE DRUG PREPARED BY SOLVENT EVAPORATION METHOD
Satish Pandav, Jitendra Naik*
ABSTRACT
Objective: Propranolol HCl loaded microparticles was prepared using
non-aqueous emulsification solvent evaporation technique having
higher Encapsulation efficiency and slower the drug release. Nondegradable
based on ammonio methacrylate copolymers containing the
hydrophilic drug Propranolol HCl were prepared with an oil-in-oil
(O/O) solvent evaporation technique by using Eudragit RSPO or
Eudragit RLPO individually or in a combination of both polymer . Our
objective was to apply this technique in order to develop highly water
soluble drugs loaded microparticles with both these copolymers.
Method: In the present work we have selected antihypertensive drug
Propranolol HCl due to its short half life and highly water solubility for
the preparation of sustained release microparticles using modified O/O
Emulsion Solvent Evaporation method. The sustained release
microparticles of Propranolol HCl with Eudragit in the different ratios of 1:1, 1:3, 1:5 and 1:7
(wt/wt) were prepared using span 80 as a surface active agent. Results: Evaluate the obtained
microparticles on the basis of percentage batch yield, encapsulation efficiency, effect of
surfactant concentration, phase volume ratio and polymer concentration. The obtained
microparticles were subjected to FT-IR, X-Ray powder diffractometry, and scanning electron
microscopy (SEM) as well as kinetic drug release study. The Eudragit loaded microparticles
were spherical with diameters in the range of 56.66 – 167.66 μm by O/O method.
Microparticles prepared by combination of Eudragit RSPO and Eudragit RLPO shows
maximum encapsulation efficiency (87.70±0.7205) than microparticles prepared by individual polymer at higher drug polymer ratio (1:7). In vitro drug release rate was faster
from formulations prepared using 0.9 % v/v surfactant concentration than those prepared
using 0.6 % surfactant concentration. Microparticles prepared by using lower phase volume
ratio shows higher encapsulation and minimum drug release than those prepared using
maximum phase volume ratio as a external phase. Conclusion: It is concluded that Eudragit
loaded sustained release microparticles of Propranolol HCl can be successfully prepared
using the non-aqueous emulsification solvent evaporation method.
Keywords: Propranolol HCl, Non-aqueous emulsification Solvent Evaporation method; Eudragit, Sustained release, Kinetic release.
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