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Satish Pandav, Jitendra Naik*


Objective: Propranolol HCl loaded microparticles was prepared using non-aqueous emulsification solvent evaporation technique having higher Encapsulation efficiency and slower the drug release. Nondegradable based on ammonio methacrylate copolymers containing the hydrophilic drug Propranolol HCl were prepared with an oil-in-oil (O/O) solvent evaporation technique by using Eudragit RSPO or Eudragit RLPO individually or in a combination of both polymer . Our objective was to apply this technique in order to develop highly water soluble drugs loaded microparticles with both these copolymers. Method: In the present work we have selected antihypertensive drug Propranolol HCl due to its short half life and highly water solubility for the preparation of sustained release microparticles using modified O/O Emulsion Solvent Evaporation method. The sustained release microparticles of Propranolol HCl with Eudragit in the different ratios of 1:1, 1:3, 1:5 and 1:7 (wt/wt) were prepared using span 80 as a surface active agent. Results: Evaluate the obtained microparticles on the basis of percentage batch yield, encapsulation efficiency, effect of surfactant concentration, phase volume ratio and polymer concentration. The obtained microparticles were subjected to FT-IR, X-Ray powder diffractometry, and scanning electron microscopy (SEM) as well as kinetic drug release study. The Eudragit loaded microparticles were spherical with diameters in the range of 56.66 – 167.66 μm by O/O method. Microparticles prepared by combination of Eudragit RSPO and Eudragit RLPO shows maximum encapsulation efficiency (87.70±0.7205) than microparticles prepared by individual polymer at higher drug polymer ratio (1:7). In vitro drug release rate was faster from formulations prepared using 0.9 % v/v surfactant concentration than those prepared using 0.6 % surfactant concentration. Microparticles prepared by using lower phase volume ratio shows higher encapsulation and minimum drug release than those prepared using maximum phase volume ratio as a external phase. Conclusion: It is concluded that Eudragit loaded sustained release microparticles of Propranolol HCl can be successfully prepared using the non-aqueous emulsification solvent evaporation method.

Keywords: Propranolol HCl, Non-aqueous emulsification Solvent Evaporation method; Eudragit, Sustained release, Kinetic release.

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