Abstract

FORMULATION AND EVALUATION OF MATRIX TABLETS USING DIFFERENT NATURAL POLYMERS

Pratibha Rani* and Vandana Verma

ABSTRACT

The prolonged release glibenclamide matrix tablets were prepared using natural polymeric materials, namely, Guar Gum and Xanthun Gum. In the formulations prepared the polymers were used in combination in different ratios as well as individually. The gums were able to retard glibenclamide release from matrix tablets in a concentration, dependent manner, but the rate of retardation differed among the polymers. The influence of polymer type and concentration on the physical properties and dissolution of the tablets were investigated. Guar gum and Xanthun gum are used as rate controlling polymer in the matrix formulations. The natural gums used were in the concentration of 15%, 30%, 45%, and 60% for the formulation of matrix tablets with each polymer. The matrix tablet using both the natural polymers in combination was also prepared. The combination of polymers (Guar gum + Xanthun gum) were in the following concentration 5 + 25%, 10 + 20%, 15 + 15%, 20 + 10%, 25 + 5% in the five formulations respectively. The excipients used in the formulation of matrix tablet were Magnesium Stearate, Talc, PVP K30, and Lactose.Compressed tablets were evaluated for uniformity of weight, content of active ingredient, friability, hardness, in vitro dissolution study and swelling index. Among the two types of polymers and concentrations studied, the dissolution profile of matrix tablets containing 30% guar gum was similar to that of matrix tablet containing 45% of xanthun gum while formulation with combination of both polymers (20 + 10%) concentration also has similar dissolution profile.

Keywords: Glibenclamide, Extended Release, Matrix Tablet, Guar Gum, Xanthun Gum.