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  • WJPPS MARCH ISSUE PUBLISHED
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Abstract

SPECTROPHOTOMETRIC ESTIMATION OF AMBROXOL HYDROCHLORIDE IN BULK AND TABLET FORMULATION

Suma.B.V.*, Kannan.K, Madhavan. V, Chandini R Nayar

ABSTRACT

A simple and sensitive spectrophotometric method in visible region has been developed for the estimation of ambroxol hydrochloride in bulk drug and in tables. In this method the free amino group of ambroxol hydrochloride reacts with ninhydrin reagent in alkaline medium to form a violet color chromogen which is determined spectrophotometrically at 567 nm. The optimum experimental condition for effect of heating, concentration of ninhydrin reagent and buffers were determined. It obeyed the Beer’s law range 2-10μg/ml. Percentage purity of drug in formulation by this proposed method was found to be 99.60%. The proposed method was found to be simple, accurate and precise method for routine estimation of ambroxol hydrochloride in bulk and from tablet dosage form.

Keywords: Ambroxol hydrochloride, ninhydrin, spectrophotometric.


[Full Text Article]

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