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  • WJPPS JULY ISSUE PUBLISHED
  • JULY 2018 Issue has been successfully launched on 1 July 2018

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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Abstract

RESTORATION OF PATHOLOGICAL CHANGES IN KIDNEY TISSUES FROM DIET INDUCED OBESE RATS TREATED WITH RHINACANTHUS NASUTUS (LINN) KURZ LEAF EXTRACT

D. Sajeda*, L. Lakshaman Kumar, K. Peera and K. Thyaga Raju

ABSTRACT

Obesity is an important cause of kidney diseases and it has close association with diabetes and hypertension and excess weight. The present study was designed to identify the kidney damage like vacuolisation in obesity induced rats and restoration of normaly after treatment with methanolic leaf extract of Rhinacanthus nasutus (R. nasutus). The methanolic leaf extract of R.nasutus (RNME) was orally administered to rats, 200mg/kg/day, while orilistat was administered of 25 mg/kg/day for 6 weeks before being sacrificed. The fat induced vacuolization, glomeruli atrophy of epithelial cells and dark pyknotic nuclei were restored to almost normal upon the treatment of rats with RNME.

Keywords: Obesity, vacuolisation, RNME, glameruli atrophy, pyknotic nuclei, orilistat.


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