Photo Gallery

Login

Search

News & Updation

  • WJPPS JULY ISSUE PUBLISHED
  • JULY 2018 Issue has been successfully launched on 1 July 2018

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  

Abstract

OXIDATION OF PREGABALIN BY POTASSIUM DICHROMATE IN ACID MEDIUM: A KINETIC AND MECHANISTIC STUDY

Syed Yousuf Hussain*, Sayyed Hussain, Mazahar Farooqui and Sayyed Salim

ABSTRACT

Kinetics of oxidation of pregabalin using potassium dichromate as oxidizing agent in acid medium was studied spectrophotometrically at 520 nm. The result interprets that rate of oxidation is first order with respect to potassium dichromate and fractional order with respect to pregabalin where as it does not depend on the concentration of acid. The stoichiometry of the reaction was found that two moles of oxidant is consumed for oxidation of three moles of pregabalin and the product found is 2(2-methyl propyl) butan-di-oic acid. From the results of kinetic studies, reaction stoichiometry and product analysis, the reaction is proposed with suitable mechanism. Based on results of the reaction at different temperatures, the activation parameters with respect to the slow step of the proposed mechanism was calculated.

Keywords: Kinetics, Oxidation, Pregabalin, Potassium Dichromate, Mechanism.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More