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  • WJPPS JULY ISSUE PUBLISHED
  • JULY 2018 Issue has been successfully launched on 1 July 2018

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  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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Abstract

SIMULTANEOUS DETERMINATION OF ANAESTHETIC AND ANTIBOTIC IN FLUID BY ELECTOCHEMILUMINESCENCE COUPLING CAPILLARY ELECTROPHORESIS

Dongdong Wang, Ziwei Zhao, Su Ming* and Shigang Shen

ABSTRACT

The coupling of electrochemiluminescence (ECL) with capillary electrophoresis (CE) was developed for the simultaneous determination of lidocaine and lomefloxacin in human urine. Under the optimized conditions: ECL detection at 1.15 V, 20 mM phosphate buffer at pH 6.7, 5 mM Ru(bpy)32+ and 60 mM phosphate buffer at pH 7.6 in the detection reservoir, detection limits of 0.02 μg mL-1 for lidocaine and 0.06 μg mL-1 for lomefloxacin were obtained. Relative standard derivations of the ECL intensity and the migration time were 3.5 and 1.1% for 6 μg mL-1 lidocaine, 3.2% and 3.7% and 1.2% for 6 μg mL-1 lomefloxacin, respectively. Developed method was successfully applied to determine the amounts of lidocaine and lomefloxacin in human urine. A baseline separation for lodocaine, proline and lomefloxacin was achieved within 10 min.

Keywords: Electrochemiluminescence, Capillary electrophoresis, Lidocaine, Lomefloxacin.


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