SERUM INTERLEUKIN-6 AND GASTRIC MUCOSA EXPRESSION OF CD3 AND CD20 IN DYSTHYROID RATS
Ajayi Ayodeji Folorunsho*, Adelakun Ayodele Ademola, Abidoye Oluwafemi Emmanuel, Adeleye Gbenga Sunday and Madukwe Jonathan
ABSTRACT
Thyroid hormones are vital to regulating growth, calorigenesis and
metabolic rate throughout life. They act on almost all organs
throughout the body, including the gut and visceral, therefore
disturbances in thyroid function may have gastrointestinal
manifestations and their effects on body tissues have concomitant
influence on the immune system. Interleukin-6 (IL-6) is a proinflammatory
cytokine which increases with gastric mucosa damage,
while, cluster differential (CD3) and cluster differential (CD20) are
markers of cell-mediated and humoral-mediated immune responses
respectively. This study, therefore, examined the expression of CD3
and CD20 in gastric mucosa with the changes in serum concentration
of IL-6 in response to altered thyroid state. The thyroid status of 30 male Wistar rats was
altered using carbimazole (hypothyroid) and levothyroxine (hyperthyroid) and the serum
interleukin-6 (IL-6), as well as gastric mucosa CD3 and CD20 expression, were assessed. It
was observed that altered thyroid state was established with the treatments given. The serum
IL-6 increased significantly (p<0.01) from 4.0 ng/ml in control to 27.0 ng/ml in hyperthyroid
and 56.3 ng/ml in hypothyroid groups. This was associated with an increased CD3 expression
in both hypothyroid and hyperthyroid groups compared to the control, while increased CD20
expression was restricted to hypothyroid rats only. Findings from this study demonstrate that alteration of thyroid state is associated with inflammatory response with consequent
immunomodulatory effect on both cells mediated- and humoral mediated immune responses.
Keywords: Cluster Differential; Hyperthyroid; Hypothyroid; Interleukin-6; Thyroid hormones.
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