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  • WJPPS JULY ISSUE PUBLISHED
  • JULY 2018 Issue has been successfully launched on 1 July 2018

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Abstract

SERUM INTERLEUKIN-6 AND GASTRIC MUCOSA EXPRESSION OF CD3 AND CD20 IN DYSTHYROID RATS

Ajayi Ayodeji Folorunsho*, Adelakun Ayodele Ademola, Abidoye Oluwafemi Emmanuel, Adeleye Gbenga Sunday and Madukwe Jonathan

ABSTRACT

Thyroid hormones are vital to regulating growth, calorigenesis and metabolic rate throughout life. They act on almost all organs throughout the body, including the gut and visceral, therefore disturbances in thyroid function may have gastrointestinal manifestations and their effects on body tissues have concomitant influence on the immune system. Interleukin-6 (IL-6) is a proinflammatory cytokine which increases with gastric mucosa damage, while, cluster differential (CD3) and cluster differential (CD20) are markers of cell-mediated and humoral-mediated immune responses respectively. This study, therefore, examined the expression of CD3 and CD20 in gastric mucosa with the changes in serum concentration of IL-6 in response to altered thyroid state. The thyroid status of 30 male Wistar rats was altered using carbimazole (hypothyroid) and levothyroxine (hyperthyroid) and the serum interleukin-6 (IL-6), as well as gastric mucosa CD3 and CD20 expression, were assessed. It was observed that altered thyroid state was established with the treatments given. The serum IL-6 increased significantly (p<0.01) from 4.0 ng/ml in control to 27.0 ng/ml in hyperthyroid and 56.3 ng/ml in hypothyroid groups. This was associated with an increased CD3 expression in both hypothyroid and hyperthyroid groups compared to the control, while increased CD20 expression was restricted to hypothyroid rats only. Findings from this study demonstrate that alteration of thyroid state is associated with inflammatory response with consequent immunomodulatory effect on both cells mediated- and humoral mediated immune responses.

Keywords: Cluster Differential; Hyperthyroid; Hypothyroid; Interleukin-6; Thyroid hormones.


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