Abstract

A STUDY OF ANTIOBESITY, HYPOLIPEDIMIC AND ANTI-ATHEROGENIC ACTIVITY OF POLY HERBAL FORMULATION AGAINST PROGESTERONE INDUCED OBESITY IN ALBINO RATS

Agrawal Amit*, Sharma Rishikesh, Pounikar Yogesh and Sharma Hemant

ABSTRACT

Obesity is one of the most common health problems and has become an epidemic on the global scale. Hyperlipidemia is one of the greatest risk factors contributing to atherosclerosis and occurrence of coronary heart diseases from the first human civilization, research is going to find the drugs to treat obesity and its complications. Despite availability of many drugs in market to treat obesity, no single drug is ideal for treating all sorts of problems caused by obesity. So the research is going on finding perfect drug. In the present study was aimed to evaluate Antiobesity, Hypolipedimic and Anti-Atherogenic activity of polyherbal formulations fruit of Emblica officinalis, Rhizome of Curcuma Longa & Leaves of Gymnema sylvestre in Progesterone albino rats.Obesity was induced in wistar albino rats by feeding them with Progesterone for 28 days. Group-I served as normal control (2% tween 80) and Group-II as obese control treated with Progesterone in arachis oil sub cutaneous, Group- III, IV were treated with various polyhebal formulations, Group-V served as positive standard (Orlistat 50 mg/kg body wt). Hyperlipidemia was induced by feeding animals with Progesterone in arachis oil sub cutaneous, daily ad libitum except normal control. The animals were treated for 28 days. At the end of the study, blood samples of the animals were sent for the estimation of the lipid profile and effects of test drug studied by comparing levels of the body weight, Total Cholesterol, Triglycerides, HDL, LDL, and Atherogenic index. The statistical significance between groups was analysed. There was a significant reduction in food intake, body weight, TC, TG, LDL and an increase in HDL levels in Progesterone rats treated Polyherbal formulation containing Emblica officinalis, Rhizome of Curcuma Longa & Leaves of Gymnema sylvestre as compared to the Positive Standard and Normal treated animals.

Keywords: Emblica Officinalis, Gymnema sylvestre, Curcuma Longa, Antiobesity, Hypolipedimic, Orlistat, Atherogenic Index, Progesterone.