Photo Gallery

Login

Search

News & Updation

  • WJPPS JUNE ISSUE PUBLISHED
  • JUNE 2018 Issue has been successfully launched on 1 June 2018

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  

Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIINFLAMMATORY ACTIVITY OF SOME NOVEL QUINOLINE DERIVATIVES

Gunda. Srilakshmi*, Dr. Srinivas R Adapa

ABSTRACT

The Inflammation is a serious health problem in industrialized country due increase in pollution. In the present study a series of new quinoline derivatives (3a-l) were synthesized and evaluated for their anti-inflammatory activity by using the model of carrageenan induced mice paw edema in adult albino rat on comparison with standard Indomethacin. The maximum anti-inflammatory activity was recorded by the compound 3i and 3j having 71% protection of edema followed by compound 3c and 3d showed 69%, compound 3b and 3e having 64% protection of edema. The compound 3i and 3j showed more percentage protection of edema with compared with standard drug Indomethacin (75%). It has been found that the extent of increase in paw volume reduces significantly up to 5 hrs when compared with solvent control.

Keywords: Anti-inflammatory activity, Carrageenan, Indomethacin, Quinoline.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More