Abstract

INVITRO AND INSILICO ACTIVITIES OF COSTUS IGNEUS LEAF EXTRACTS ON ALPHA AMYLASE - AN ANTIDIABETIC STUDY

Khoushika Raajshree R.* and Chitra P.

ABSTRACT

Diabetes mellitus is a group of metabolic disorders characterized by a chronic hyperglycemic condition due to disturbances in glucose homeostasis. Phytocompounds play a major role in modulating glucose metabolism by inhibition of carbohydrate digesting enzyme like α-amylase. The ethanolic extract of Costus igneus had high invitro α- Amylase inhibition percentage than all other extracts. Gas Chromatography-Mass Spectrometry analysis was performed for the ethanol extract and the compounds obtained were docked against the target Human Pancreatic Alpha-Amylase. Phytol was found to be an active compound through insilico docking with the least E value of – 6.51 kcal/mol. The results are expected to be useful in conducting invivo screenings on animal model which may lead to the development of more effective and potent new chemical entities with antidiabetic property.

Keywords: ?-amylase, Costus igneus, Gas Chromatography-Mass Spectrometry, Phytol, antidiabetic property.