NEW FORMULATION AND EVALUATION OF DOMPERIDONE SUSPENSION
Saritha Chukka, Shankaraiah Puligilla, Madhusudan Rao Yamsani*
ABSTRACT
Objective of the work was carried out the formulation and evaluation
of Domperidone suspension. methods: new formulations were made
with the flocculated and deflocculated the domperidone drug
suspension with different flocculating agents of AlCl2, Cacl2 and used
SLS(formulation code DS1-DS10), HPMC (deflocculating),
Sod.CMC(formulation code DN1-DN10) as suspending agents,
performed the conductivity studies , stability studies for 6 months,
influence of ageing and natural ageing on sedimentation volume, pH,
Conductivity and dissolution rate were assessed, Results: results were
obtained depending on the concentration of flocculating & suspending
agents there was increased sedimentation volume, Conductivity but
there is no change on pH, dissolution rate is increased. Conclusion:
concluded that the based on the sedimentation volume, rate of settling,
ease of redispersibility and optimum release, DN8 & DS10 formulations were selected as best
formulations and compared with marketed product Domperidone suspension.
Keywords: Domperidone, flocculating agents, deflocculating agents, dissolution, sedimentation volume, redispersibility.
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