FORMULATION AND EVALUATION OF TERBUTALINE SULPHATE PULSATILE DRUG DELIVERY SYSTEM
Nandvishal V. Deore*, Vinod M. Thakare, Bharat W. Tekade, Vijay R. Patil.
TVES’s H.L.M.C. College of Pharmacy, Faizpur- 425503, Tal. Yawal Dist. Jalgaon, Maharashtra, India.
ABSTRACT
Present research work was planned to developed a novel dosage form
using a chronopharmaceutical approach. A pulsatile dosage form,
taken at bedtime with a programmed start of drug release can prevent
a sharp increase in the incidence of asthmatic attacks, during the early
morning hours. The powedr blend was evaluated for pre compression
parameters. The pulsatile formulation was prepared by direct
compression method by using different concentrations of guar gum.
After that ten batches are selected and coated with enteric coated
polymer shellac. Prepared tablets were evaluated for post compression
parameters. Tablets were subjected to in-vitro drug release study in
1.2 pH and 7.4 pH. The formulation F8 shows significant behaviour
pattern compared with other formulations.
Keywords: Terbutaline sulphate; Colon Delivery System; shellac.
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