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  • WJPPS SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2018 Issue has been successfully launched on 1 September 2018

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
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  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
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Abstract

PREPARATION OF INSULIN-PLGA IMPLANT AND ITS EFFICACY STUDY

Guang Yang, Jiawei Chen, Na Zhao, Chenchen Yang, Liandong Hu*

ABSTRACT

To prepare Insulin-PLGA implants and to investigate the drug release profiles. The implant tablets were prepared using PLGA as carrier and CMC-Na or HA as pore forming agent. The tablets were investigated in vivo and in vitro. SEM showed there were many discontinuous pores in the cross-section of the implants, the release of PLGA/HA implants was rapid, while PLGA/CMC-Na implants released slowly, and the hypoglycemic effect of PLGA/CMC-Na implants at the ratio of 2.5:1 was more than 108 h. Insulin-PLGA implants have good hypoglycemic effects, and can be used as a promising sustained-release preparation for insulin delivery.

Keywords: Insulin microsphere; Implant; Chitosan; PLGA; Blood glucose; Determination; Sustained release.


[Full Text Article]

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