Abstract

PREPARATION OF INSULIN-PLGA IMPLANT AND ITS EFFICACY STUDY

Guang Yang, Jiawei Chen, Na Zhao, Chenchen Yang, Liandong Hu*

ABSTRACT

To prepare Insulin-PLGA implants and to investigate the drug release profiles. The implant tablets were prepared using PLGA as carrier and CMC-Na or HA as pore forming agent. The tablets were investigated in vivo and in vitro. SEM showed there were many discontinuous pores in the cross-section of the implants, the release of PLGA/HA implants was rapid, while PLGA/CMC-Na implants released slowly, and the hypoglycemic effect of PLGA/CMC-Na implants at the ratio of 2.5:1 was more than 108 h. Insulin-PLGA implants have good hypoglycemic effects, and can be used as a promising sustained-release preparation for insulin delivery.

Keywords: Insulin microsphere; Implant; Chitosan; PLGA; Blood glucose; Determination; Sustained release.