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  • WJPPS MARCH ISSUE PUBLISHED
  • MARCH 2019 Issue has been successfully launched on 1 March 2019

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  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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Abstract

DOCKING STUDIES AND SYNTHESIS OF N-MANNICH BASES OF ISATIN DERIVATIVES AND THEIR BIOLOGICAL ACTIVITY

Dr. R.A. Hajare*, A.D. Chavhan

ABSTRACT

A series of different schiffs bases of 5-substituted-1H indole-2,3 dione were synthesized by refluxing ethanol with different aromatic primary amine and hydrazine.Then a series of different mannich bases were synthesized from schiffs bases of different 5-substituted-1H indole-2,3 dione with different secondary aromatic amine in presence of formaldehyde. In the present study designed for docking studies considered that derivatives of isatin demonstrated protective activity against convulsion. Isatin is a versatile starting material for the synthesis of number of organic compounds. Structures of the synthesized compounds were confirmed by FT-IR, 1H-NMR, 13C and mass spectral data.

Keywords: Docking, isatin, anti-convulsant.


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