Abstract

EFFECT OF AILANTHUS EXCELSA EXTRACT IN HEPATIC DISORDERS

*Deepti Bonde, Vivek Kahale, Mukund Tawar and Nilesh Choudhary

ABSTRACT

Objectives of the present Investigations is to study hepatoprotective activity of methanol and aqueous extract of leaves of Ailanthus excelsa. Desired plant part was collected, air dried at room temperature in shadow and coarsely ground. The powdered material of leaves was extracted with methanol and distilled water in Soxhlet apparatus. Duration of the study was 10 days. All the animals were sacrificed on the 11th day for the estimation of various bio-chemical parameters like SGOT, SGPT, ALP, and TB. Control group animal showed decreased level of TP compared to normal significantly. Treatment with Silymarin, Methanolic extract, Aqueous extract of A.excelsa significantly increased serum albumin level. Silymarin and Methanolic extract (400mg) more effective than Methanolic extract (200mg) Aqueous extract (400mg) and Aqueous extract (200mg) of A.excelsa. Carbon tetrachloride induced hepatotoxicity was significantly prevented by pretreatment with methanolic and aqueous extracts of A.excelsa leaves the preventive effect causing reduction in elevated biochemical parameter levels like serum ALT, AST, ALP and total bilirubin and increase in serum total protein and serum albumin levels after methanolic and aqueous extract treatment has confirmed the hepatoprotective effect of A.excelsa leaves in liver damage models in rats and near restoration of hepatic cells with minor fatty change and absence of necrosis was also identified with the histological slides.

Keywords: Ailanthus excelsa, Hepatoprotective, Methanolic extract, Aqueous extract.