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  • WJPPS MAY ISSUE PUBLISHED
  • May 2018 Issue has been successfully launched on 1 May 2018

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Abstract

FORMULATION AND EVALUATION OF ORAL DISINTEGRATING TABLET OF TELMISARTAN

L. Satyanarayana* and N. Sandeepthi

ABSTRACT

Telmisartan is selective angiotensin II receptor and it is used in treatment of hypertension, heart failure. The oral disintegrating Tablets as recently developed drug delivery systems. Telmisartan should be administrated orally once or twice daily for a total daily dose of 4 to 32 mg. In this investigation oral disintegrating Tablet were prepared by using super disintegrating agent crospovidone, croscaremellose sodium, sodium starch glycolate in concentration 3%, 4%, 5%. Sweeteners and flavours were used to enhance the organoleptic properties of Tablet. Tablets were prepared by direct compression technique. Formulated oral disintegrating Tablets were evaluated for weight variation, friability and disintegration time, drug content, wetting time, water absorption ratio and in vitro drug release. The results show that the all formulations satisfied the limits of oral disintegrating Tablet. The formula [F9] that contain 5% crospovidone as superdisintegrant shows the best results with a disintegrating time 31 sec, hardness 3.7 kg/cm2 and drug release rate 98.08% within 10 min.

Keywords: Telmisartan, oral disintegrating Tablet, crospovidone.


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