FORMULATION AND EVALUATION OF MUCCOADHESIVE BUCCAL TABLETS OF TIZANIDINE HYDROCHLORIDE BY USING POLYMETHYLOLCARBAMIDE: A NOVEL MUCCOADHESIVE POLYMER
Hariprasanna R.C *1, 2, S.S.Bushetti 3
1Research Scholar, Acharya Nagarjuna University, Guntur. India.
2R.M.E.S’s College of Pharmacy, Old Jewargi Road, Gulbarga-Karnataka. India.
3H.K.E.S’s College of Pharmacy, Sedam Road, Gulbarga-Karnataka. India.
ABSTRACT
The buccal region offers an attractive route of administration for
systemic drug delivery. The mucosa has a rich blood supply and
provides rapid absorption for drugs than oral route.Tizanidine is a
non-selective, α-2 adrenergic agonist receptor. Because of poor
bioavailability of Tizanidine by oral route, there is a need to increase
its bioavailability by formulating it into buccal dosage forms. Hence,
Tizanidine is a suitable drug for buccal dosage forms and may provide
a better therapeutic profile than oral route. In the present investigation
Tizanidine Hydrochloride Buccal tablets were prepared by using
novel muccoadhesive polymer Polymethylolcarbamide (PMC) in
comparison with the standard HPMC K15. The prepared tablets were
evaluated for weight variation, thickness, hardness, friability, surface
pH, swelling index, muccoadhesive strength, In- vitro drug release
and In-Vivo muccoadhesive behavior of optimized formulation. All
the formulations displayed zero order kinetics. Higuchi and Peppas data reveals that the drug
released by non-Fickian diffusion mechanism. The in vitro release parameter values
displayed by the various formulations fabricated by HPMC shows, formulation TH I (40%
polymer) was released more than 90% of drug within 3hrs, formulation TH II (40% polymer)
was released more than 90% of drug at 4th hr, and in case of formulation TH III (50% polymer) was released more than 90% of drug at the end of 6th hr. In case of formulations
fabricated by novel polymer PMC, formulation TP I (40% polymer) was controlled the drug
release up to 6th by releasing 93.65%, formulation TP II was released 75.65% drug at the end
of 6th hr whereas formulation TP III was released 70.16% at the end of 6th hr. from these
results it was concluded that the novel PMC is more superior than existing polymers in order
to control the drug release.
Keywords: Tizanidine Hydrochloride, Novel muccoadhesive polymer, PMC, HPMC K15.
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