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Abstract

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET OF DOMPERIDONE USING FENUGREEK SEED MUCILAGE AS NATURAL SUPERDISINTEGRANT BY DIRECT COMPRESSION METHOD.

Ashok Kumar Sharma*, Dr. Vandana Sharma, Shankar Lal Soni, Ramesh Pareek, Rakesh Kumar Goyal and Mohit Khandelwal

ABSTRACT

The demands for fast dissolving tablets have received ever increasing day to day during the last 2-3 decades. In the present designed in-vitro study, the effect of natural superdisintegrant was compared with synthetic super disintegrants and conventional super disintegrants in the of fast dissolving tablet formulation of Domperidone. Dopamine is an antiemetic drug which used for the management of the vomiting treatment, and cancerous nausea. In the present work 9 formulations of FDT (Fast dissolving tablet) of Domperidone were prepared by using isolated mucilage of the fenugreek seed (Mucilage) was evaluated and compiles with the official parameters and specifications. Various formulations were prepared using four different superdisintegrsnts namely- fenugreek seed mucilage, sodium starch glycolate, cross carmelose sodium with three concentrations (2%, 4%, 6%) by direct compression method. The blend was evaluated for pre-compression parameters like Angle of repose, bulk density, tapped density and then tablet evaluated post-compression parameters like thickness, drug content, hardness, weight variation, wetting time, friability, disintegration time, dissolution time, drug release study. Formulation 8 showed the lowest disintegration time and invitro dissolution studies recorded that formulation 8 showed 99.50% drug release at the end of 3 minutes. The best formulations were also found to be stable and optimized formulations were subjected to the stability studies as per ICH guideline.

Keywords: Antiemetic, fenugreek seed mucilage, sodium starch glycolate, Domperidone, Gastric antrum, dissolution time.


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