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Abstract

DESIGN AND FORMULATION OF FAST DISSOLVING TABLET OF LORNOXICAMUSING BANANA POWDER AS NATURAL SUPERDISINTEGRANT BY DIRECT COMPRESSION METHOD.

Maniratna Nareda*, Ashok Kumar Sharma, Siddharth Nareda, Madhavi Ghadge, Dr. Shiv Garg and Dr. Piush Sharma

ABSTRACT

The demands for fast dissolving tablets have received ever increasing day by day during the last 15 years. In the present designed study, the effect of Natural superdisintegrant was compared with synthetic super disintegrants and conventional super disintegrants in the of fast dissolving tablet formulation of Lornoxicam. Lornoxicamis a potent NSAID of oxicam class with analgesic anti-inflammatory and antipyretic properties with management of pain, inflammatory disease of joints, osteoarthritis, surgery sciatica and other inflammations. In the present work 9 formulations of FDT (Fast dissolving tablet) of Lornoxicam were prepared by using isolated Raw Banana powder was evaluated and compiles with the official parameters and standard specifications. Various formulations were prepared using four different superdisintegrants namely- Banana, sodium starch glycolate, cross carmelose sodium with three concentrations (2%, 4%, 6%) by direct compression method. The blend was evaluated for various pre-compression parameters like Angle of repose, tapped density, and then tablet evaluated post-compression parameters like thickness, drug content, hardness, weight variation, wetting time,friability, disintegration time, dissolution time, drug release study. Formulation 5 showed the lowest disintegration time and in-vitro dissolution study data recorded that formulation 5 showed 99.25% drug release at the end of 3 minutes. The best formulations were also found to be standard and optimized formulations were subjected to the stability studies as per ICH guideline.

Keywords: Fast dissolving tablet, NSAID, Lornoxicam, Banana powder, sodium starch glycolate, direct compression, dissolution time.


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