WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

EVALUATION OF INVIVO ANTIDIABETIC ACTIVITY OF WHOLE PLANT EXTRACTS OF EUPHORBIA CYATHOPHORA ON STREPTOZOTOCIN INDUCED DIABETIC RATS

A. Vigneshwari, *Sakthi Abirami M. and Monika N.

ABSTRACT

Diabetes is metabolic disorder characterized by hyperglycaemia, glycosuria, negative nitrogen balance and ketonaemia. The objective of this study is to evaluate Invivo anti diabetic activity of whole plant extracts of Euphorbia cyathophora on Streptozotocin induced diabetic rats. Acute toxicity studies were followed as per OECD guidelines 423. The anti-diabetic activity of Euphorbia cyathophora was evaluated in diabetic wistar rats. Diabetes was induced by intra-peritoneal injection of Streptozotocin 50mg/kg body weight. The anti-diabetic effect of plant extracts was compared with standard drug Glibenclamide. The biochemical parameters such as alkaline phosphatase, acid phosphatase, lactate dehydrogenase, urea, creatinine, lipid profile, tissue homogenate enzymes and lysosomal enzymes were estimated. In vivo study reveals that animal treated with ethanolic extract of Euphorbia cyathophora shows significant reduction in blood glucose, body weight, triglycerides, HDL, cholesterol in Streptozotocin induced diabetic rats. In Euphorbia cyathophora treated group, there was a significant reduction of enzymes such as Alkaline phosphatase, Acid phosphatase, lactate dehydrogenase and no significant increase in urea and creatinine level when compared to the control group which reveals the protective nature of the plant source. It concludes that Invivo antidiabetic activity of whole plant extracts of Euphorbia cyathophora on normal and Streptozotocin induced diabetic rats was evaluated and concluded that it possesses anti-diabetic activity.

Keywords: Euphorbia cyathophora, diabetes, Drug - Streptozotocin induced, hypoglycaemic effect.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More