Photo Gallery

Login

Search

News & Updation

  • WJPPS OCTOBER ISSUE PUBLISHED
  • OCTOBER 2018 Issue has been successfully launched on 1 October 2018

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  

Abstract

SYNTHESIS, CHARACTERIZATION, AND ANTI-BACTERIAL ASSESSMENT OF NEW GATIFLOXACIN ANALOGUES

Noor H. Nasser*, Meison Abdulbary, Sarah H. Shaalan and Esraa S. Hadi

ABSTRACT

New gatifloxacin analogues were synthesized by coupling with different sulfonamide derivatives (sulfanilamide, and sulfacetamide), using chloroacetyl chloride linker, in order to increase the bulkiness at position 7 of the flouroquinolone by that reduce the efflux of the antibiotic from the bacterial cells and bacterial resistance will reduced consequently. The chemical structures of the synthesized compounds were confirmed and characterized using FT-IR spectroscopy, and elemental microanalysis, in addition to some physicochemical properties as melting points and Rf values. The antibacterial study was showed comparable effect of the prepared compounds with Gatifloxacin. The largest inhibition zone was observed with compound IIa against bacteria Bacillus cereus and the lowest inhibition zone was observed with compound IIa against bacteria Proteus mirabilis.

Keywords: Gatifloxacin, Flouroquinolones, Bacterial resistance, Topoisomerase enzyme.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More