Abstract

SYNTHESIS AND EVALUATION OF SOME NOVEL BENZIMIDAZOLE AND QUINOLONE DERIVATIVES FOR THEIR ANTIFUNGAL AND ANTIDIABETIC ACTIVITY

Rekha Muluk*, Prajakta Kothawade, Gauri Kulkarni and Pramode Ingale

ABSTRACT

A series of novel benzimidazole and Quinolone derivatives have been synthesized and evaluated for antifungal and antidiabetic activity. The newly synthesized compounds have been characterized by IR, 1HNMR and elemental analyses. All the compounds have been found to promising antifungal activity when compared with standard drug Griseofulvin. All the compounds were screened for in-vitro antidiabetic activity by α-glucosidase inhibitory action by different concentration like 150 g/ml, 200 g/ml by inhibition of α- glucosidase method. Acarbose was used as standard drug.

Keywords: antifungal activity, antidiabetic activity, elemental analyses, Acarbose Griseofulvin, ?-Glucosidase.