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  • WJPPS MARCH ISSUE PUBLISHED
  • MARCH 2019 Issue has been successfully launched on 1 March 2019

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  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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Abstract

BIOAVAILBILITY ENHANCEMENT OF ARTESUNATE USING SOLID DISPERSION TECHNIQUES

Shaundarya Kumar *, Dr.Dinesh Chandra, Rakesh Singh, Vijay Kumar Singh, Usha Rai, Vaibhav Prakash Srivastava

ABSTRACT

In the present work, an attempt has been made to enhance solubility and dissolution of poorly water soluble drug, Artesunate by preparing solid dispersions using two hydrophilic polymers namely ,β- cyclodextrin and PEG 6000.Drug carrier solid dispersions were prepared by solvent Physical mixing method. Solid dispersions of Artesunate with β-cyclodextrin and PEG 6000 markedly increase the solubility and dissolution of solid dispersion compared to the free form of Artesunate. The results were compared with marketed tablet of Artesunate. The drug carrier interactions in the solid state were investigated using saturated solubility studies, FTIR spectroscopy, Xray diffraction and differential scanning calorimeter. The developed formulation overcome and alleviates the drawbacks and limitations of Artesunate sustained release formulations and could possibility be advantageous in terms of increased bioavailability of Artesunate.

Keywords: Artesunate, Solid dispersion. Bioavailability enhancement, ?-cyclodextrin.


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