Abstract

PHYTOCHEMICAL SCREENING AND ANTICONVULSANT ACTIVITY ALCOHOLIC LEAF EXTRACT OF CALOTROPIS GIGANTEA LINN

G. Sabari*, T. Anju, G. Sireesha, B. Sowjanya, K. Devendr Sri Sai and Dr. T. Satyanarayana

ABSTRACT

Calotropisgigantealinn is a perennial shrub, commonly known as milkweed or wasteland weed. It belongs to family Asclepiadaceae and was evaluated for its anticonvulsant activity. The leaves were extracted with 100% ethanol and concentrated to obtain residue. The alcoholic extract (ALE) at a dose of 400 mg/kg b.w, 300 mg/kg b.w, 200 mg/kg b.w and 100 mg/kg b.w by i.p route were tested for their anticonvulsant property against Maximum Electric Shock (MES) induced convulsion model in Swissalbino mice of either sex weighing between 18 g -22 g. A significant (p < 0.01) anticonvulsant activity had been observed in the ALE (400 mg/kg b.w and 300 mg/kg b.w) followed by ALE (200 mg/kg b.w and 100 mg/kg b.w) when compared to control group. Phytochemical screening reveals the presence of alkaloids, cardiac glycosides, flavonoids, steroids, tannins, triterpenoids, carbohydrates and saponins in the alcoholicleaf extract of Calotropisgigantealinn.

Keywords: Calotropisgigantealinn, alcoholic extract, Maximum electric shock.