Abstract

FORMULATION AND EVALUATION OF ORAL DISINTEGRATING TABLETS OF NIMODIPINE

Sd. Shahabaz*, C. Soujanya and M. Kishore Kumar

ABSTRACT

The aim of this research is to formulate and evaluate nimodipine oral disintegrating tablets. Nimodipine binds specifically to L-type voltagegated calcium channels the inhibition of calcium ion transfer results in the inhibition of vascular smooth muscle contraction. Evidence suggests that the dilation of small cerebral resistance vessels, with a resultant increase in collateral circulation, and/or a direct effect involving the prevention of calcium overload in neurons may be responsible for nimodipine's clinical effect in patients with subarachnoid hemorrhage. Hence, in this investigation an attempt was made to develop oral disintegrating tablets of Nimodepine with super disintegrating agents like crosspovidone, crosscarmellose sodium, sodium starch glycolate with superior dissolution properties with different concentrations like 2%,4%,6%,8%,10%,12% individually by using diluents like D-Mannitol and Micro crystalline cellulose phosphate by direct compression method. The tablets were evaluated for the precompression parameters such as bulk density, compressibility, angle of repose etc and post compression parameters like hardness, weight variation, friability, disintegration time, in-vitro dissolution profiles and stability studies. The formulation F15 consisting of 1:1 ratio crosspovidone, crosscarmellose sodium was found to be the best among all the formulations because it has exhibited faster disintegration time (17.66 sec) when compared to the other formulations and it showed 99.87±0.18% drug release in 25 min. and there were no changes occurred in the stability.

Keywords: Nimodipine, D-Mannitol, crosspovidone, crosscarmellose sodium.