Abstract

ANALYSIS OF THE EFFECT OF SILDENAFIL (VIAGRA) ON NITROGENOUS BASES OF RNA AND DNA USING QUANTUM METHOD

Juan Jesús García-Mar, Oscar Sánchez-Parada*, Manuel Aparicio-Razo, Emmanuel Vázquez-López, Iliana Herrera-Cantú, Karina García-Aguilar, Erick Pedraza-Gress, Lillhian Arely Flores-González and Manuel González-Pérez

ABSTRACT

Sildenafil is a medication used to treat male erectile dysfunction. It is an inhibitor of one of the phosphodiesterases, and during clinical studies, it was found to be more effective in the treatment of impotence. Sildenafil is active in 70% of the subjects with the impotence of diverse etiology. The objective of the study is to determine the interactions of the drug vs. nitrogenous bases (NBs). The Hyperchem Professional software was used the parametric semiempirical parametric method 3 (SE-PM3). It was found that the interactions of the pure NBs and the drug have a very high probability that they occur. The interactions of the pairs of BNs and sildenafil also have a very high probability that they will occur. In both cases, it can be predicted that this drug brings many health problems including mutations.

Keywords: Sildenafil, Nitrogen Bases, Quantum method, Hyperchem, SE-PM3.