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  • WJPPS MARCH ISSUE PUBLISHED
  • MARCH 2019 Issue has been successfully launched on 1 March 2019

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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Abstract

METHOD DEVELOPMENT AND VALIDATION OF BENZALKONIUM CHLORIDE IN MARKETED FORMULATION BY UV-VISIBLE SPECTROPHOTOMETRY USING SILVER NITRATE AND EOSIN SOLUTION

Parth Patel*, Priya Varshney, Dhara Patel, Dhananjay Meshram

ABSTRACT

A simple, accurate and precise UV-Visible Spectrophotometric (UVVIS) method has been developed and validated for analysis of Benzalkonium chloride both as the bulk drugs and in formulations. Analysis of Benzalkonium chloride was performed at 517 nm. Regression analysis data for the calibration plots were indicative of good linear relationships between absorbance and concentration over the range of 1-5 ug/ml. The correlation coefficients, R2, were 0.999. The values of slope and intercept of the calibration plots were 0.062 and 0.216 respectively. The method was validated for linearity, accuracy, and precision.

Keywords: Benzalkonium chloride, UV-Visible spectrophotometric method, eye drops, accuracy, precision.


[Full Text Article]

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