Photo Gallery

Login

Search

News & Updation

  • WJPPS JULY ISSUE PUBLISHED
  • JULY 2018 Issue has been successfully launched on 1 July 2018

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  

Abstract

FORMULATION, STATISTICAL OPTIMIZATION AND EVALUATION OF INCLUSION COMPLEXED FAST ORAL DISSOLVING FILMS OF CARVEDILOL

G. Swathi*, K. Brahma, B. Moulika Lakshmi, S. Sravani, P. Indira and Dr. P. Shailaja

ABSTRACT

Carvedilol is a β-blocker, belongs to BCS class II, with low oral bioavailability (25%), primarily used for the treatment of hypertension, and heart failure, after a heart attack to improve the chance of survival, prevents strokes kidney problems. The purpose of this research is to formulate carvedilol as oral dissolving films to provide an immediate release of drug and fast onset of action, thereby improving the bioavailability. The films are prepared by solvent casting method using polymers such as HPMC, PVA and PVP in different composition in addition with poly ethylene glycol-400 as plasticizer. The formulated films are assessed for their physicochemical parameters such as transparency, thickness, weight variation, folding endurance, surface pH, disintegration time, swelling studies and drug content uniformity, in vitro dissolution study. The optimized films were characterized for interaction studies by FT-IR. To increase the percentage of drug release at minimum duration, the drug with β cyclodextrin is prepared as inclusion complex by kneading method using 32 factorial design, the optimized inclusion complex mixture was incorporated into the films, and further optimized by the evaluation studies. The optimized non-inclusion complexed and inclusion complexed FDF formulations were evaluated for Ex-vivo drug release study using porcine oral mucosa and stability studies.

Keywords: Carvedilol, Fast Dissolving Films, Solvent Casting, Kneading Method, Inclusion Complexation, Non-Inclusion Complexed FDFs.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More