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Pitchiah Kumar Murugan* and Kaliyamurthi Venkatachalam


Oxidative stress is considered to be one of the most significant factors that contribute to life threatening disease like myocardial infarction. From the recent research it was evident that medicinal plants with potential antioxidant activity will alleviate the condition of oxidative stress and its related pathology. The main aim of the present research work is to evaluate the antioxidant potential of aqueous, alcoholic and hydro alcoholic extracts of the plant Strychnos potatorum by in vitro DPPH, Nitric oxide, Hydrogen peroxide and ABTS radical scavenging assays. Epicarp of Strychnos potatorum Linn was extracted with water, Ethanol and mixture of Ethanol: water (6:4) (hydro-alcoholic extract) by using soxhlet extraction method. The respective extracts were screened for antioxidant activity by in vitro assay techniques. The results obtained from the study reveals that all the three extracts showed promising antioxidant activity in which the ethanol extract (EESP) projects highest significant activity followed by aqueous (AESP) and hydro-alcoholic (HAESP) extracts. In DPPH radical scavenging assay EESP exhibit strong scavenging activity the equivalent percentage inhibition ranges from 25.96 to 81.04% followed by this AESP with inhibition of 22.03 to 79.25% and HAESP with percentage inhibition of 24.89 to 77.46%. Results of nitric oxide radical assays shows that EESP shown higher percentage inhibition of 22.82 to 72.1% similarly AESP with 12.93 to 35.37% and HAESP with 5.18 to 44.22% inhibition. In hydrogen peroxide radical inhibition assay EESP contributes higher inhibition percentage of 16.68 to 74.98% whereas AESP with 6.12 to 60.57% and HAESP with 7.81 to 63.85%. Result of NO radical scavenging property reflects that EESP projects highest inhibition of 22.82 to 72.1% followed by this AESP with 12.93 to 35.57% and HAESP with 5.18 to 44.22%. Datas obtained from ABTS radical scavenging assay clearly reflects that EESP has higher percentage inhibition of 26.31 to 78.79% followed by this AESP with inhibition of 12.69 to 51.95% and HAESP with percentage inhibition of 10.68 to 67.17%. It was concluded from the results that EESP had shown the highest radical scavenging activity among the extractives when compare to that of the standard’s. In future epicarp of Strychnos potatorum may be considered as a valuable natural antioxidant source for scavenging free radical. It may be developed as a potential plant based therapeutic moiety for treating diseases caused by free radicals.

Keywords: Oxidative stress, Free radicals, Strychnos potatorum, Antioxidant activity, DPPH, Nitric oxide, Hydrogen peroxide, ABTS scavenging assays.

[Full Text Article]

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