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  • WJPPS OCTOBER ISSUE PUBLISHED
  • OCTOBER 2018 Issue has been successfully launched on 1 October 2018

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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Abstract

ANALYSIS OF THE EFFECT OF LEVODOPA ON NEUROTRANSMITTERS USING QUANTITY METHOD

Manuel Aparicio-Razo*, Oscar Sánchez-Parada, Javier Flores-Mendez, Jorge Tzompantzi-Texis, Nora Mercedes Sánchez-Parada and Manuel González-Pérez

ABSTRACT

The Benefit of the Levodopa or L-Dopa (LEV) to reduce the symptoms of Parkinson’s disease and have been studied and presented a concern for promoting the acceleration of neurodegeneration. The objective of the study is to determine, using the parametric semiempirical quantum method 3 (SE-PM3), that neurotransmitter (NT) has a higher affinity with LEV through Hyperchem professional software; it is possible to perform molecular models and analysis of the LEV and the nine primary NT. The result of the simulations of the quantum sediments reveals that Serotonin is the primary NT oxidized by the presence of LEV, correlating with multiple pathologies linked to the side effects of that drug.

Keywords: Levodopa, Neurotransmitters, Quantum Method, Hyperchem, SE-PM3.


[Full Text Article]

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