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Abstract

SYNTHESIS OF SOME 1,3-THIAZOLE CONTAINING 2,3- DIHYDROXY BENZYLIDENE AMINO MOIETY AS ANTITUMOR AGENTS

Mohamed Abd El-Moneim, Jehan A. Hasanen* and Maha El-Ashry

ABSTRACT

2-[2,3-dihydroxybenzylidene)amino]-4-phenyl and/or (5-phenyl)-1,3- thiazole were obtaines via the cyclization of 2,3- dihydroxybenzaldehyde thiosemicarbazone (1) with phenacyl bromide under different conditions. Acetylation, alkylation, halogenation and condensation reactions of 2-[(2,3-dihydroxybenzylidene)amino]-5- phenyl-1,3-thiazole (3) yielded the corresponding triacetyl derivatives (4), N-alkyl derivatives (5 and 6), bromo derivatives (7) and arylidene derivatives (9). The structure of the 1,3-thiazole derivatives was confirmed by IR, NMR, MS spectra and elemental analyses. The antitumor activity of synthesized 1,3-thiazole derivatives were evaluated on human breast and liver cancer cell lines. As a result of the cell culture studies, all of the prepared compounds showed anticancer activity for breast and liver cancer cells. In conclusion, novel 1,3-thiazole derivatives might be potentially useful in the field of cancer treatment.

Keywords: .


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