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  • WJPPS OCTOBER ISSUE PUBLISHED
  • OCTOBER 2018 Issue has been successfully launched on 1 October 2018

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  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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Abstract

DIFFERENT METHODS FOR THE ANALYSIS OF EMPAGLIFLOZIN IN THE PRESENCE OF ITS OXIDATIVE DEGRADATION PRODUCT

Fathy M. Salama, Khalid A. M. Attia, Ahmed A. Abouserie, Ragab A. Mabrouk and Ahmed M. Abdelzaher*

ABSTRACT

Three rapid, simple, accurate and precise spectrophotometric methods were used for the determination of Empagliflozin in the presence of its oxidativec degradation product. The methods under study are ratio derivative, ratio difference and mean centering. All the methods were validated according to the ICH guidelines and the obtained accuracy, precision and repeatability were found to be within the acceptable limits. The selectivity of the proposed methods was tested using laboratory prepared mixtures and assessed by applying the standard addition technique. So, they can be used for the routine analysis of Empagliflozin in quality-control laboratories.

Keywords: Empagliflozin; Stability-indicating; Ratio derivative; Ratio difference; Mean centering.


[Full Text Article]

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